Polynucleotides
At Dr Home Aesthetics, we specialise in regenerative, medical-grade treatments that work with your skin - not against it.
Polynucleotides are one of the most exciting advancements in aesthetics, designed to repair, rejuvenate and regenerate skin at a cellular level for long-lasting improvement.
What are polynucleotides?
Polynucleotides are highly purified DNA fragments derived from natural sources.
When injected into the skin, they activate your fibroblast cells - stimulating the production of collagen, elastin and hyaluronic acid while improving oxygenation and microcirculation.
The result? Skin that feels firmer, smoother and more radiant, with a visible glow that develops gradually over time.
This treatment focuses on restoring function, not changing appearance - perfect for those seeking natural, healthy rejuvenation.
Benefits
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Restores skin elasticity and firmness
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Improves texture, tone, and hydration
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Calms redness and inflammation
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Supports skin barrier repair
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Brightens dull, tired complexions
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Safe for delicate areas including the eyes and neck
Common treatment areas with polynucleotides
​Polynucleotides can rejuvenate almost any area of the face or body where skin health needs a boost:
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Face and neck
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Eye area (for dark circles or fine lines)
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Décolletage
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Hands
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Scalp (for hair density and health)​
At Dr Home Aesthetics, we use Nucleofill®, a leading polynucleotide brand derived from salmon DNA — chosen for its exceptional purity and biocompatibility.
Nucleofill® works through three key mechanisms:
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Biostimulation – encouraging fibroblast activity to rebuild collagen and elastin.
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Antioxidation – protecting the skin from free radical damage.
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Hydration – improving moisture retention and restoring suppleness.
Because it’s based on natural DNA molecules, Nucleofill® integrates safely into your skin’s own repair processes, making it ideal for sensitive or reactive skin types.
Frequently asked questions
Are polynucleotides the same as fillers?
No - polynucleotides don’t add volume. They work by stimulating your own skin to repair and rejuvenate itself from within.
Is Nucleofill® safe?
Yes. Nucleofill® is derived from purified salmon DNA and is highly biocompatible with human tissue. It has an excellent safety profile and is widely used in Europe for skin regeneration.
Does the treatment hurt?
Most clients describe only mild discomfort or stinging. A topical anaesthetic cream can be applied beforehand if needed.
How soon will I see results?
You’ll start to notice improved hydration and glow within a couple of weeks, with firmer, smoother skin developing over 4–6 weeks.
How many sessions do I need?
A course of three treatments spaced a few weeks apart is recommended initially, followed by one maintenance session every 4–6 months.
Is there any downtime?
Only minimal - you may experience mild redness or small bumps at injection sites, which settle within 24 hours.