When it comes to skincare, there’s a big difference between products you pick up at the supermarket and those you get from a doctor or dermatologist. You might have heard terms like over-the-counter (OTC), medical-grade, and prescription skincare, but what do they really mean?
In this blog post, we will break down the distinctions among these skincare product types, explore their active ingredients, and outline the benefits and results you can expect from each one.
Understanding Over-the-Counter (OTC) Skincare Products
✔️ Available at: pharmacies, supermarkets, beauty retailers (e.g. Boots, Sephora)
✔️ Strength: Mild – lower concentrations of active ingredients
✔️ Best for: General skincare, mild concerns
✔️ Examples: Retinol serums from high-street brands, basic vitamin C serums, own brand hyaluronic acid serums.
OTC skincare includes products like basic cleansers, moisturisers, and serums featuring vitamin C or retinol that anyone can buy without a prescription. These products contain low concentrations of active ingredients to ensure they’re safe for the general public. While they can be effective over time, they often take longer to show results because they are not as potent. One significant advantage of OTC products is their accessibility and affordability.

Diving into Medical-Grade Skincare
Also Called Cosmeceuticals or Professional Skincare
✔️ Available at: Clinics, dermatologists, aesthetic practitioners, medical spas, online
✔️ Strength: Higher concentrations than OTC, but still not prescription-only
✔️ Best for: Targeting specific skin concerns like acne, pigmentation, and ageing
✔️ Examples: ZO Skin Health, Obagi, AlumierMD, SkinCeuticals, Dermalogica, retinol creams stronger than OTC but weaker than prescription tretinoin.
Medical-grade skincare sits between OTC and prescription skincare. These products often feature higher concentrations of active ingredients, aimed at more targeted treatments, that have been clinically tested to penetrate deeper into the skin compared to OTC products. While you don’t need a prescription, they are usually recommended by skincare professionals who can guide you on the best routine for your skin type.

The Power of Prescription Strength Skincare
✔️ Available at: Clinics, dermatologists, prescribed by a doctor
✔️ Strength: The highest potency, regulated as medicine
✔️ Best for: Severe acne, pigmentation, deep wrinkles, rosacea
✔️ Examples:
• Tretinoin (Retin-A, the strongest form of topical Vitamin A) – for acne, photoageing, fine lines and wrinkles
• Hydroquinone – for pigmentation and melasma
• Azelaic acid (15-20%) – for rosacea, acne, and melasma
• Topical antibiotics for acne
Prescription strength skincare can only be obtained through a licensed healthcare provider. These products contain the most potent active ingredients, ensuring targeted treatment for conditions like severe acne, significant hyperpigmentation, and advanced ageing signs. These products require a doctor’s supervision because they are contraindicated in certain conditions, can cause irritation, peeling, or other side effects if used incorrectly.
Prescription tretinoin stands out among retinoids due to its enhanced effectiveness at the cellular level. Research shows that tretinoin can achieve visible results in as little as six weeks for issues like acne and photoageing. This makes it a go-to choice for individuals seeking swift improvements in their skin’s overall tone and texture.
Similarly, prescription vitamin C products often have much higher concentrations than OTC or medical-grade versions. These potent formulations can boost collagen production and target deeper pigmentation, leading to rejuvenated skin and diminished age-related signs.

Choosing the Right Product for Your Skin
Which Type of Skincare Should You Use?
• Mild concerns or prevention? OTC skincare is fine.
• Want stronger results with scientifically proven ingredients? Medical-grade skincare is the best balance.
• Treating acne, severe pigmentation, or signs of ageing? Prescription skincare gives the most dramatic results but must be used under guidance.
Closing Thoughts
Navigating the skincare landscape can seem daunting, given the vast array of products available. Understanding the differences between OTC, medical-grade, and prescription-strength items is essential for effective skincare.
Incorporating the right products into your regimen can yield transformative results, helping you achieve vibrant, healthy skin. No product will work miracles overnight; consistent use, aligned with a sound skincare routine, is vital for maximising effectiveness.
If you’re unsure, a consultation with a skincare professional can help you find the right products for your skin goals!
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